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Search Guidelines and other CDMTs

In this section you will find the list of Clinical Practice Guidelines (CPGs) and other Clinical Decision Making Tools (CDMTs) compiled and classified on Quality Domains. Please go to Guidelines and other CDMTs Section to see the methodology followed.

*Please note that classification for CPGs and other CDMTs on Bleeding and Coagulation disorders and Lymphoid malignances on Quality Domains is ongoing. Documents will be searchable soon.

Search guidelines

Recommendations regarding splenectomy in hereditary hemolytic anemias

Subnetwork: Bone marrow failure, Red blood cell defects

Disease group/s: Alpha- thalassaemia disorders, Beta- thalassaemia disorders, Congenital dyserythropoietic anemia (CDA), Hereditary Elliptocytosis, Hereditary Spherocytosis, Hereditary Stomatocytosis, Pyruvate Kinase Deficiency, Red blood cell enzyme defects (Other than PKD), Sickle cell disorders

Scope and Purpose: 3. Treatment

Patients' involvement?: No

Rigour of development: A - Evidence and consensus based

Link: https://www.ncbi.nlm.nih.gov/pubmed/28550188

American Association for the Study of Liver Diseases.Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases

Subnetwork: Haemochromatosis and other iron disorders

Disease group/s: HFE-related hereditary hemochromatosis with established severe clinical expression or due to very rare mutations in HFE

Scope and Purpose: 5. Diagnosis and treatment

Patients' involvement?: No

Rigour of development: A - Evidence and consensus based

Link: https://www.ncbi.nlm.nih.gov/pubmed/21452290

Comment:

Some divergences with the European guidelines (namely on the value of the H63D variant). 

Practice guidelines for the diagnosis and management of microcytic anemias due to genetic disorders of iron metabolism or heme synthesis

Subnetwork: Haemochromatosis and other iron disorders

Disease group/s: Defects in heme synthesis or Fe-S cluster biogenesis: Sideroblastic anemias (SLC25A38, GLRX5; HSPA9), XLSA with ataxia (ABCB7), XLSA (ALAS2), Low iron availability for erythropoiesis: Iron Refractory Iron deficiency Anemia (IRIDA), Aceruloplasminemia (ACP), Rare defects in iron acquisition and transport: Atransferrinemia, Microcytic anemia with iron loading (DMT1), Sideroblastic anemia (STEAP3)

Scope and Purpose: 5. Diagnosis and treatment

Patients' involvement?: Yes

Rigour of development: A - Evidence and consensus based

Link: https://www.ncbi.nlm.nih.gov/pubmed/24665134

Harmonemia: a universal strategy for flow cytometry immunophenotyping-A European LeukemiaNet WP10 study

Subnetwork: Myeloid malignancies

Disease group/s: Transversal

Scope and Purpose: 2. Diagnosis

Patients' involvement?: No

Rigour of development: A - Evidence and consensus based

Link: https://www.ncbi.nlm.nih.gov/pubmed/26922887

Comment:

Project aimed at harmonizing diagnostic protocols adopting the highest quality experimental methodology. Current methodology assessment scale not applicable. 

Guidelines for the diagnosis and management of adult aplastic anaemia

Subnetwork: Bone marrow failure

Disease group/s: Acquired Aplastic anemia (Other than PNH), Blackfan-Diamond anemia (BDA), Constitutional aplastic anemia (Other than BDA, FA, Dyskeratosis congenita and Shwachman-Diamond syndrome), Dyskeratosis congenita, Fanconi Anemia (FA), Paroxysmal Nocturnal Hemoglobinuria (PNH), Shwachman-Diamond syndrome

Scope and Purpose: 5. Diagnosis and treatment

Patients' involvement?: No

Rigour of development: B - Consensus based

Link: https://www.ncbi.nlm.nih.gov/pubmed/26568159

Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes

Subnetwork: Bone marrow failure

Disease group/s: Acquired Aplastic anemia (Other than PNH), Blackfan-Diamond anemia (BDA), Constitutional aplastic anemia (Other than BDA, FA, Dyskeratosis congenita and Shwachman-Diamond syndrome), Dyskeratosis congenita, Fanconi Anemia (FA), Paroxysmal Nocturnal Hemoglobinuria (PNH), Shwachman-Diamond syndrome

Scope and Purpose: 3. Treatment

Patients' involvement?: No

Rigour of development: B - Consensus based

Link: https://www.ncbi.nlm.nih.gov/pubmed/26052913

Prevention and Diagnosis of Haemoglobinopathies: A Short Guide for Health Professionals and Laboratory Scientists

Subnetwork: Red blood cell defects

Disease group/s: Alpha- thalassaemia disorders, Beta- thalassaemia disorders

Scope and Purpose: 2. Diagnosis

Patients' involvement?: No

Rigour of development: B - Consensus based

Link: http://thalassaemia.org.cy/publications/tif-publications/prevention-and-diagnosis-of-haemoglobinopathies-a-short-guide-for-health-professionals-and-laboratory-scientists/

Comment:

Ed. 2016

Handbook for newborn laboratories: NHS Sickle Cell and Thalassaemia Screening Programme

Subnetwork: Red blood cell defects

Disease group/s: Alpha- thalassaemia disorders, Beta- thalassaemia disorders, Sickle cell disorders

Scope and Purpose: 1. Prevention

Patients' involvement?: No

Rigour of development: B - Consensus based

Link: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/585126/NHS_SCT_Handbook_for_Newborn_Laboratories.pdf

Comment:

Antenatal Laboratory Handbook SCD Thal

Transplantation for bone marrow failure: current issues

Subnetwork: Bone marrow failure

Disease group/s: Acquired Aplastic anemia (Other than PNH), Blackfan-Diamond anemia (BDA), Constitutional aplastic anemia (Other than BDA, FA, Dyskeratosis congenita and Shwachman-Diamond syndrome), Dyskeratosis congenita, Fanconi Anemia (FA), Paroxysmal Nocturnal Hemoglobinuria (PNH), Shwachman-Diamond syndrome

Scope and Purpose: 3. Treatment

Patients' involvement?: No

Rigour of development: C - Expert opinion

Link: https://www.ncbi.nlm.nih.gov/pubmed/27913467

Molecular diagnosis of hemochromatosis

Subnetwork: Haemochromatosis and other iron disorders

Disease group/s: non-HFE related hereditary hemochromatosis: (HH types 2A, 2B, 3 and 4A,4B ), TFH1-Related Hemochromatosis (type V), Hereditary Hyperferritinemia Cataract Syndrome

Scope and Purpose: 2. Diagnosis

Patients' involvement?: No

Rigour of development: C - Expert opinion

Link: https://www.ncbi.nlm.nih.gov/pubmed/23530886

The EBMT-ELN working group recommendations on the prophylaxis and treatment of GvHD: a change-control analysis

Subnetwork: Myeloid malignancies

Disease group/s: Transversal

Scope and Purpose: 6. Prevention, diagnosis, treatment

Patients' involvement?: No

Rigour of development: C - Expert opinion

Link: https://www.ncbi.nlm.nih.gov/pubmed/27892949

Comment:

Survey aimed at evaluating how effectively the information in the recommendations had reached the centres, studying the attitudes of the centres and the impact of the recommendations on centre policies.