Pathogenesis of inherited thrombocytopenia

Speakers: Hana Raslova

Professor Hana Raslova, PhD, is co-leader of the INSERM team "From stem cell to megakaryocyte" located at the Institut Gustave Roussy in Villejuif, France. She has a long-time expertise in normal and pathological megakaryopoiesis. Her research is focused on the regulation of megakaryocyte ploidization and differentiation and on the pathophysiological mechanisms of rare inherited thrombocytopenia with and without predisposition to acute myelogenous leukemia. For several years she has been closely collaborating with clinicians from the Reference Center for Platelet Pathologies, and by studying patients' primary cells and using patient-derived or genetically modified iPSCs, her team identified the mechanisms leading to different inherited thrombocytopenia.

She is also involved in the European consortium working on high-scale platelet production from iPSCs and modeling inherited thrombocytopenia for drug testing in a 3D system.